Product Detail
Tianeptine is neuroprotective via multiple neurochemical and cellular mechanisms. In theory, tianeptine's neuroprotective action makes it a potential life-extension drug. When an organism is under stress, or perceives itself under stress, the hypothalamus secretes corticotropin-releasing hormone/factor (CRH/CRF). CRH/CRF in turn increases secretion of adrenocorticotrophic hormone (ACTH) from the anterior pituitary. ACTH in turn stimulates the release of glucocorticoids from the adrenal cortex. Persistent, uncontrolled physical and psychosocial stress causes excess cortisol secretion from the adrenal glands. Excess cortisol causes dendritic shrinkage in the hippocampus and a contrasting growth of dendrites in the lateral amygdala. These stress-induced changes tend to lower mood; they can cause clinical depression in the genetically vulnerable. Current evidence suggests that tianeptine acts to prevent and even reverse stress-induced neural damage, promoting both neuronal survival and synaptic plasticity.
COA:
TestsSpecificationsResults
DescriptionWhite to yellowish powder, very hygroscopic.Off-white powder, very hygroscopic.
SolubilityFreetly soluble In water and methanol and dichloromethaneComplies
Identification(1)By IR, To match with working standardComplies
(2)It gives reaction of sodiumComplies
Impurities A≤0.1%Not detected
Related compoundsAny impurity ≤0.1%<0.1%
Total impurities ≤0.4%0.25%
Residual SolventsAcetidin≤ 0.5%Not detected
Dichloromethane≤ 0.06%Not detected
Methanol≤ 0.3%Not detected
Acetone ≤ 0.5%Not detected
Acetonitrile≤0.041%Not detected
Ethanol≤0.5%0.04%
N, N-dimethylformamide≤0.088%Not detected
Water≤ 5.0%1.38%
Assay99.0%-101.0%(On anhydrous basis)99.98%
ConclusionConform to EP8.0
Applicant:
Tianeptine has strong antidepressant and anxiolytic properties with a relative lack of sedative, anticholinergic and cardiovascular adverse effects, thus suggesting it is particularly suitable for use in elderly patients and in those following alcohol withdrawal; such patients can be more sensitive to the adverse effects of psychotropic drugs. Recent interesting results indicate anticonvulsant and analgesic activity of tianeptine and its possible interaction with adenosine A1 receptors.
Chemical & Physical Properties
Density1.4±0.1 g/cm3
Boiling Point609.2±65.0 °C at 760 mmHg
Melting Point129-131°C
Molecular FormulaC21H25ClN2O4S
Molecular Weight436.952
Flash Point322.2±34.3 °C
Exact Mass436.122345
PSA95.09000
LogP2.57
Vapour Pressure0.0±1.8 mmHg at 25°C
Index of Refraction1.639
Store in a cool and ventilated warehouse. Keep away from fire and heat source. The storage temperature should not exceed 32 ºC, and the relative humidity should not exceed 80%. Keep away from light. The package shall be sealed and shall not come into contact with air. Provide corresponding varieties and quantities of fire-fighting equipment. The storage area shall be equipped with leakage emergency treatment equipment and appropriate receiving materials
Packaging & Shipping
Liquid:
Iron drum & plastic drum packaging
25kg per unit
100kg per unit
200kg per unit
1 ton per unit
Solid
Plastic bag & kraft paper bag & fiber drum
1kg per bag/drum
25kg per bag/drum
Packing:
1.Inner double plastic bags----25kg/Fiber drum (35*35*45cm, GW: 28kg,NW: 25kg);
2.Inner double plastic bags----5kg/Aluminum foil bag (GW: 6.5kg, NW: 5kg).
3.Inner double plastic bags----1kg/Aluminum foil bag (GW: 1.5kg,NW: 1kg).
Price negotiable based on order quantity
Payment Term West Union /Bitcoin/ Money Gram/TT
Delivery Time normally 5-10 days by express
Shipping way Express(EMS,DHL, TNT, FedEX, HKDHL, EUB, China Post, NL Post and other couriers), Door to Door
Shipping Period Within 5-12 days for most countries
Contact Us:
nicole@whaop.com
Whatsapp/Skype/Telegram:
+86-13229075933
Wickr:pharmanicole
