CAS:5413-05-8;High quality 99% Purity PMK/BMK Ethyl 2-phenylacetoacetate

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未来时间1801

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Product Name:Ethyl 2-phenylacetoacetate
CAS:5413-05-8
MF:C12H14O3
MW:206.24
EINECS:226-500-0
Melting point 140-144°C/10mm
Boiling point 140-144°C 10mm
density 1,085 g/cm3
refractive index 1.5130
Fp 140-144°C/10mm
solubility Chloroform (Slightly), Methanol (Slightly)
pka10.69±0.46(Predicted)
1.It is an important pharmaceutical chemical raw material, mainly used in the synthesis of the intermediates of the fourth and fifth generation of new cephalosporin antibiotics
2.It is an ester organic matter and can be used as a medical intermediate.
3.(1) Firstly, the mixture of ethyl acetoacetate and toluene was prepared in a certain proportion, and then the mixture and iodobenzene were injected into the micro-channel reactor by a metering pump at a certain proportion of flow rate, and the discharge temperature of the reactor was controlled at 5 ~ 10℃. Then the prepared saturated salt water and reaction liquid are mixed continuously stratified, the lower layer is the reaction liquid, the upper layer of salt water.
(2) Under atmospheric pressure, the reaction liquid after washing is slowly heated. When the bottom temperature of the kettle reaches 55℃, toluene begins to be steamed out of the Chemicalbook. When the temperature of the kettle reaches 100℃ (to ensure the solvent is completely steamed out), the heating is stopped and the distilled solvent is collected and cooled.
(3) After recovery of solvent, under vacuum degree -0.1MPa, decompress-distillation, slow temperature, when the temperature of the kettle 85 ~ 90℃, control reflux ratio of 4, began to steam out of finished products, when the temperature of the kettle rose to 120℃, stop heating, and turn off the vacuum pump, qualified product 2-phenyl ethyl acetoacetate, and measured its chromatographic content.

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